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KMID : 1189420070200020108
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 2 p.108 ~ p.115
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Effect of Scutellariae Radix Extract on the release of chemokines induced by TNF-a and IL-4 in A549 cells
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Kim Sung-Ho
Kim Hee-Taek
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Abstract
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Objectives: In the present study, the effect of Scutellariae radix on the release of RANTES, eotaxin, TARC induced by TNF-a and IL-4 in human bronchial epithelial cell(A549 cell) was examined. Scutellariae radix significantly inhibited the secretion of RANTES, eotaxin, TARC with a dose-dependant manner.
Methods: In the experiment, to observe the toxity of the cell according to concentration of Scutellariae radix, MIT assay was carried out to examine cell viability. The effective dosage did not have the cytotoxicity on human bronchial epithelial cell in all control group excepting 50 ug/ml$ concentration.
Results: The above results shows Scutellariae radix inhibits the secretion of the release of RANTES, eotaxin, TARC on human bronchial epithelial cell(A549 cell).
Conclusion: These results suggest that Scutellariae radix could be used as a prophylaxis and remedy of asthma induced by allergy and inflammatory reaction caused by several reasons.
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KEYWORD
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Scutellariaeradix, athma, RANTES, eotaxion, TARC, humanbronchialepithelialcell(A549cell)
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